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Endocrine Abstracts

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ea0073oc7.4 | Oral Communications 7: Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Liver GPR55 regulates NAFLD progression from steatosis to fibrosis

Fernández Uxía , Fernández Fondevila Marcos , González Rellán María Jesús , Da Silva Lima Natalia , Buque Xabier , González Rodríguez Marta , Delgado Teresa , Varela Rey Marta V , Eva Novoa , Tojo Marta , Marta Miguel , Diéguez Carlos , Diéguez Miguel , DiéguezMaría Luísa , Arrese Marco , García-Monzón Carmelo , Mato Jose , Aspichueta Jose , Nogueiras Rubén

Background and aimsG protein-coupled receptor 55 (GPR55) is a putative cannabinoid receptor, and l-α-lysophosphatidylinositol (LPI) is its only known endogenous ligand. Although GPR55 has been linked to energy homeostasis in different organs, its specific role in lipid metabolism in the liver and its contribution to the pathophysiology of non-alcoholic fatty liver disease (NAFLD) remains unknown.MethodWe...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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